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Formulation Development & Screening

At Helix Biotech, we've developed our own manufacturing platform - the Nova Impinged Jet Mixer (IJM) -  to quickly and reliably screen nanoparticle formulations, such as lipid nanoparticles (LNP), liposomes, emulsions, and polymer-based particles.

Orange Capsules

Selecting the Right Nanoparticle Formulation

Our team of scientists select from a library of well known and novel lipid- or polymer-based formulations, sourced from our partners and suppliers, to optimize the encapsulation, targeted delivery, and expression of your API. 

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Nova Design Optimization - Our Nova experts apply the Design of Experiments concept in combination with our Nova Benchtop scale screening to help optimize your formulation, improve your delivery system and therapeutics, and accelerate your project success.

 

We help identify key variables that have the greatest impact on formulation stability and efficacy, and determine the optimal parameters to achieve your goals. 
 

Leadtimes as low as 2 weeks

How we decrease LNP leadtimes

1) We synthesize and acquire high quality mRNA and lipid reagents to lower acquisition time.

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2) We've innovated automated manufacturing platform (i.e. the Nova™ IJM)  to streamline nanoparticle production for a wide sample volume range (microliter to liter scale).

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3) Our highly experienced and educated Nova team has decades of liposome, LNP, and manufacturing experience to help optimize your nanoparticle production.

LNP Expertise in GMP Manufacturing and Scale Up

Even during the screening stage, we have a pathway to scaling up your manufacturing. Our expertise is in designing manufacturing systems (Nova IJM flash nanoprecipitation/FNP and TWIST liposome extrusion) and in GMP manufacturing of drug products which helps us streamline your development process.
 
We will help you design the optimal system to increase output and keep reagent, analytical, and FTE costs at a minimum.

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