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Helix Biotech's EZNano DLin-MC3-DMA LNP is a pre-formulated lipid nanoparticle with the following components:

 

50% - DLin-MC3-DMA (Ionizable Cationic Amino Lipid)

10% - 1,2-distearoyl-sn-glycero-3-PC (1,2-DSPC, Phospholipid)

38.5% - Cholesterol

1.5% - DMG-PEG(2000) (Lipid Excipient)

 

The EZNano DLin-MC3-DMA LNP can come with a variety of lipophilic dyes (DiO, DiI, DiD, and DiR), and can be loaded with mCherry, eGFP or FLuc mRNA.

 

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EZNano DLin-MC3-DMA LNP

PriceFrom $227.59
  • *Empty LNPs are provided at an equivalent concentration of lipids and volume.

    **EZNano LNPs include a small amount of cryoprotectant to aid in longterm frozen storage.

  • Table 1. mRNA-LNP QC

    Attributes Specifications
    Particle Size 70-100 nm
    PDI <0.2
    Encapsulation Efficiency >90%
    mRNA Concentration 100 µg/mL ± 10%
    Dye Concentration 0.1%, mol
    Volumes 5.5µg = 55µL or 11µg = 110µL
    Storage -80°C

    *QC data measured after subjecting LNPs to freeze-thaw cycle

     

    Table 2. Excitation & Emission Values

    Dye/Fluorescent Protein Excitation (nm) Emission (nm)
    eGFP 488 509
    Fluc (Firefly Luciferase) - 560
    mCherry 587 610
    DiO 484 501
    DiI 549 565
    DiD 644 665
    DiR 750 780

     

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